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Buy phentermine 37.5 capsules daily in a dose of 150 mg/day) for four weeks. One study evaluated the effects of a single 300 mg dose of phentermine combined with a low-dose (0.5 mg/kg/day) of the non-selective N-methyl-D-aspartate (NMDA) antagonist ketamine on the memory deficits and behavioral sensitization described below in post-mortem human cortex from rats who received a single 30-day ketamine treatment without any administration of phentermine 27 days earlier ( ). The acute behavioral effects of phentermine were studied in animals using the Morris water maze and Y-maze procedures described in the Introduction. animal and procedure were approved by the Institutional Animal Care and Use Committee of Stanford University. Ketamine The drug ketamine has been used in experimental depression the past. It has limited use in humans. After intravenous (IV) administration (20-150 mg/kg) of ketamine, animals show severe tolerance (i.e., prolonged withdrawal syndrome) after chronic treatment, and the animals exhibit a depressive-like behavior similar to the acute effects of phentermine. development withdrawal symptoms on from ketamine was examined in the context of above studies using a dose-response and time-course model of withdrawal ( ). Rats (6 months old) were pretreated (1 mg/kg/day) with saline or phentermine in their drinking water for 10 days and then given ketamine (0.5 mg/kg/day, 2 times per week) hours later for the last 4 days of study. The administration ketamine produced significant behavioral and neurochemical side effects, the animals exhibited a depressive behavior similar to that of phentermine. The withdrawal signs were manifested at approximately 8 hours after the first infusion; rats were not able to tolerate the administration of ketamine after last dose ( ). A similar withdrawal syndrome with an initial stage and ongoing was observed in all animals ketamine or phentermine groups after the last injection. For each dose level, the time interval between dose and withdrawal symptoms at week 4, and their correlation with the cumulative dose, were compared. In addition to withdrawal symptoms, ketamine-dependent rats showed an improvement of depressive-like behavior in the Morris water maze test and delayed swimming in the Y-maze test when compared with saline-dependent animals. Chronic ketamine treatment produced the same effect of recovery effects chronic phentermine and prevented any behavioral deficits. Chronic ketamine treatment was effective in restoring the acute and chronic changes in the BDNF protein levels prefrontal cortex. A study using repeated dose-response trial design confirmed that the acute effects of combined administration ketamine and phentermine in rats were dose-dependent. The acute behavioral and neurochemical effects of this combination ketamine and phentermine did not differ when compared with that of the single dose ketamine. In this study, the cumulative doses of phentermine and ketamine were equal to 5 mg/kg and 1.5 mg/kg, respectively, did not produce depressive-like behavior in rats ( ). Dextromethorphan Dextromethorphan is a mild anticholinergic agent which was found to have anxiolytic effects when administered chronically (up to 7 days) with a low daily dose (5 mg) of the non-selective metabolite 3-Methoxy-morphinan in rats, whereas it was anxiolytic in rats without a prior exposure to dextromethorphan (see the Introduction). A repeated dose study on the combination between dextromethorphan and phentermine showed that the anxiolytic effect of dextromethorphan alone with phentermine was more pronounced in the chronic studies (p<0.001 N-methyl-D-aspartate (NMDA) -induced tail suspension and Y-maze) than in the baseline studies (p<0.001 Morris water maze and Y-maze tests) ( ). Furthermore, the antidepressant effect of dextromethorphan in the two studies was more pronounced than that observed in the no drug studies N-methyl-D-aspartate (NMDA) -induced tail suspension and Y-maze tests (p<0.001 in the Morris water maze test and p<0.001 in the Y-maze test), indicating that combination of dextromethorphan and phentermine is a more efficacious treatment. Furthermore, chronic doses of dextromethorphan (as much as 75 mg/day) with the non-selective metabolite 3-Methoxy-morphinan in rats produced antidepressant-like effects, while chronic dextromethorphan treatment with both and phentermine did not produce.

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